objective(s):bone marrow-derived mesenchymal stem cells (bmscs) have attracted significant interest to treat asthma and its complication. in this study, the effects of bmscs on lung pathology and inflammation in an ovalbumin-induced asthma model in mouse were examined. materials and methods:balb/c mice were divided into three groups: control group (animals were not sensitized), asthma group (an...

Objective(s):Bone marrow-derived mesenchymal stem cells (BMSCs) have attracted significant interest to treat asthma and its complication. In this study, the effects of BMSCs on lung pathology and inflammation in an ovalbumin-induced asthma model in mouse were examined. Materials and Methods:BALB/c mice were divided into three groups: control group (animals were not sensitized), asthma group (an...

Asthma is a chronic respiratory disorder in which immunological and structural cells play role. The limits of conventional medicines necessitate the development innovative therapeutic techniques for asthma. In present study, we investigated possible protective effect cinnamic acid (CA) on ovalbumin-induced asthma mouse model. Sixty albino male mice BALB/c type weighing (20-30) grams were chosen...

we aimed to study the mntnhex-2-pyp effect on some markers of lung antioxidant defence system in mice asthma model.the study was carried out on 28 c57b1/6 mice divided into four treatment groups: group 1 - controls; group 2 - injected and inhaled with ovalbumin; group 3 - treated with mntnhex-2-pyp and inhaled with phosphate buffered saline; group 4 - injected with ovalbumin and mntnhex-2-pyp b...

In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features bronchial asthma in ovalbumin-induced murine model asthma. commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug Asian folk system medicines. work, pharmacological studies are done provide scientific evidence therapeutic plants allergic A...

Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...


 Asthma is a chronic and complex condition of the respiratory tract, that occurs in both children adults. Currently available medications have side effects; therefore, new therapies with fewer effects are needed. Thus, present study was designed to evaluate potential anti-asthmatic alcoholic extract Ammi majus on ovalbumin-induced asthma mice. Forty-eight female Albino mice were randomly ...

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that reportedly counteracts the anti-inflammatory effect of endogenous glucocorticoids. There have only been a few reports that demonstrate a potential link between MIF and bronchial asthma. In an attempt to further clarify the precise role of MIF in asthma, the present authors examined the effect of anti-MIF antibody (...